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Article

White and grey matter abnormalities in patients withSPG11mutations

13 Jun 2012

Abstract excerpt

BACKGROUND: Mutations in SPG11 are the most frequent known cause of autosomal recessive hereditary spastic paraplegia. Corpus callosum thinning is a hallmark of the condition but little is known about damage to other structures in the CNS. OBJECTIVE: To evaluate in vivo cerebral damage in patients with SPG11 mutations. METHODS: 5 patients and 15 age and sex matched healthy controls underwent high resolution...

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PMID: 22696581
DOI: 10.1136/jnnp-2011-300129

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