Article
Hereditary Spastic Paraplegia: Beyond Clinical Phenotypes toward a Unified Pattern of Central Nervous System Damage.
Radiology - 1 Jul 2015
Agosta Federica, Scarlato Marina, Spinelli Edoardo G, Canu Elisa, Benedetti Sara, Bassi Maria Teresa, Casali Carlo, Sessa Maria, Copetti Massimiliano, Pagani Elisabetta, Comi Giancarlo, Ferrari Maurizio, Falini Andrea, Filippi Massimo
Abstract excerpt
PURPOSE: To investigate whether specific patterns of brain gray matter (GM) regional volumes and white matter (WM) microstructural abnormalities and spinal cord atrophy occur in patients with pure and complicated hereditary spastic paraplegias (HSPs). Relationships between clinical and cognitive features of patients with HSP who had brain and cervical cord damage were also investigated. MATERIALS AND METHODS:...
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