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Article

Multimodal MRI-based study in patients with SPG4 mutations.

PloS one - 1 Jan 2015

Rezende Thiago J R, de Albuquerque Milena, Lamas Gustavo M, Martinez Alberto R M, Campos Brunno M, Casseb Raphael F, Silva Cynthia B, Branco Lucas M T, D'Abreu Anelyssa, Lopes-Cendes Iscia, Cendes Fernando, França Marcondes C

Abstract excerpt

Mutations in the SPG4 gene (SPG4-HSP) are the most frequent cause of hereditary spastic paraplegia, but the extent of the neurodegeneration related to the disease is not yet known. Therefore, our objective is to identify regions of the central nervous system damaged in patients with SPG4-HSP usin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25658484
DOI: 10.1371/journal.pone.0117666
PMCID: PMC4320056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25658484-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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