Article
Environmental and genetical aspects of the link between pregnancy, birth size, and type 2 diabetes.
Current diabetes reviews - 1 May 2012
Vignini Arianna, Raffaelli Francesca, Cester Annamaria, Iannilli Antonio, Cherubini Valentino, Mazzanti Laura, Nanetti Laura
Abstract excerpt
Exposure of the fetus to the intrauterine milieu can have profound effects on the health of the offspring in adulthood. These observations are highly reproducible in many populations worldwide although the mechanisms behind them remain elusive. The 'thrifty phenotype' hypothesis proposes that poor fetal nutrition leads to programming of metabolism and an adult phenotype that is adapted to poor but not plentiful...
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