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Article

The thrifty phenotype hypothesis.

British medical bulletin - 1 Jan 2001

Hales C N, Barker D J

Abstract excerpt

The thrifty phenotype hypothesis proposes that the epidemiological associations between poor fetal and infant growth and the subsequent development of type 2 diabetes and the metabolic syndrome result from the effects of poor nutrition in early life, which produces permanent changes in glucose-insulin metabolism. These changes include reduced capacity for insulin secretion and insulin resistance which, combined...

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Source

Identifiers

PMID: 11809615
DOI: 10.1093/bmb/60.1.5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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