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Detection of tumor-specific DNA methylation markers in the blood of patients with pituitary neuroendocrine tumors

23 Feb 2022

Abstract excerpt

BACKGROUND: DNA methylation abnormalities are pervasive in pituitary neuroendocrine tumors (PitNETs). The feasibility to detect methylome alterations in circulating cell-free DNA (cfDNA) has been reported for several central nervous system (CNS) tumors but not across PitNETs. The aim of the study was to use the liquid biopsy (LB) approach to detect PitNET-specific methylation signatures to differentiate these...

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PMID: 35212383
DOI: 10.1093/neuonc/noac050

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