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Article

Tripterine ameliorates monosodium urate crystal-induced gouty arthritis by altering macrophage polarization via the miR-449a/NLRP3 axis.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Mar 2021

Wang Yu

Abstract excerpt

OBJECTIVE: Tripterine (Trip) is frequently applied to alleviate inflammation in various diseases such as rheumatoid arthritis. Macrophages have both anti-inflammatory and pro-inflammatory functions. However, whether Trip can inhibit cell inflammation in gouty arthritis (GA) remains undiscovered and whether the mechanism involved in macrophage polarization is also undetermined. This paper aims to study the effects...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33559709
DOI: 10.1007/s00011-021-01439-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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