Article

Monosodium Urate Crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response

2021-04-14

Abstract excerpt

<h4>ABSTRACT</h4> How macrophages are programmed to respond to monosodium urate crystals (MSUc) is incompletely understood partly due to the use of a toll-like receptor-induced priming step. Here, using genome wide transcriptomic analysis and biochemical assays we demonstrate that MSUc alone induces an in vitro metabolic-inflammatory transcriptional program in both human and murine macrophages markedly distinct...

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Literature Corpus work: fcf44f45-76fa-5b89-8da6-4b0924b4b58b
DOI: 10.1101/2021.04.14.439881

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