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Article

Inflammatory Response to Regulated Cell Death in Gout and Its Functional Implications

6 Apr 2022

Abstract excerpt

Gout, a chronic inflammatory arthritis disease, is characterized by hyperuricemia and caused by interactions between genetic, epigenetic, and metabolic factors. Acute gout symptoms are triggered by the inflammatory response to monosodium urate crystals, which is mediated by the innate immune system and immune cells (e.g., macrophages and neutrophils), the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3)...

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PMID: 35464445
DOI: 10.3389/fimmu.2022.888306

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