A Bacillus subtilis ΔpdxT mutant suppresses vitamin B6 limitation by acquiring mutations enhancing pdxS gene dosage and ammonium assimilation.

doi:10.1111/1758-2229.12936

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Article

A Bacillus subtilis ΔpdxT mutant suppresses vitamin B6 limitation by acquiring mutations enhancing pdxS gene dosage and ammonium assimilation.

Environmental microbiology reports - 1 Apr 2021

Richts Björn, Lentes Sabine, Poehlein Anja, Daniel Rolf, Commichau Fabian M

Abstract excerpt

Pyridoxal-5'-phosphate (PLP), the biologically active form of vitamin B6, serves as a cofactor for many enzymes. The Gram-positive model bacterium Bacillus subtilis synthesizes PLP via the PdxST enzyme complex, consisting of the PdxT glutaminase and the PdxS PLP synthase subunits, respectively. PdxT converts glutamine to glutamate and ammonia of which the latter is channelled to PdxS. At high extracellular...

Topics

Ammonium Compounds
Bacillus subtilis
Gene Dosage
Mutation
Vitamin B 6

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Open in PubMed

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PMID: 33559288
DOI: 10.1111/1758-2229.12936

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