Article
Mutant gltS alleles enable a Vibrio fischeri D-glutamate auxotroph to grow with lower requirements for exogenous D-glutamate.
Microbiology spectrum - 7 Oct 2025
Coppinger Macey, Helm Richard F, Yang Liu, Ruby Edward G, Popham David L, Stabb Eric V
Abstract excerpt
D-glu is a key component of peptidoglycan (PG) and is essential for growth in most bacteria. To assess constraints on PG evolution and bacterial requirements for D-glu, we sought to artificially evolve PG biosynthesis, leading to either replacement of D-glu in the PG peptide or alternative pathways to D-glu incorporation. We previously found that suppression of D-glu auxotrophy in a murI racD mutant of Vibrio...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.