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Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera.

Nature medicine - 1 Apr 2021

Xie Xuping, Liu Yang, Liu Jianying, Zhang Xianwen, Zou Jing, Fontes-Garfias Camila R, Xia Hongjie, Swanson Kena A, Cutler Mark, Cooper David, Menachery Vineet D, Weaver Scott C, Dormitzer Philip R, Shi Pei-Yong

Abstract excerpt

We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses...

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PMID: 33558724
DOI: 10.1038/s41591-021-01270-4

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