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The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization

25 Mar 2021

Abstract excerpt

Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we report that the D614G mutation modestly reduced (1.7-2.4-fold) SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse,...

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PMID: 33767200
DOI: 10.1038/s41541-021-00313-8

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