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Article

α-synuclein impairs autophagosome maturation through abnormal actin stabilization

8 Feb 2021

Abstract excerpt

Vesicular trafficking defects, particularly those in the autophagolysosomal system, have been strongly implicated in the pathogenesis of Parkinson's disease and related α-synucleinopathies. However, mechanisms mediating dysfunction of membrane trafficking remain incompletely understood. Using a Drosophila model of α-synuclein neurotoxicity with widespread and robust pathology, we find that human α-synuclein...

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PMID: 33556113
DOI: 10.1371/journal.pgen.1009359

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