Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer

3 Feb 2021

Abstract excerpt

Telomere encompasses a (TTAGGG)n tandem repeats, and its dysfunction has emerged as the epicenter of driving carcinogenesis by promoting genetic instability. Indeed, they play an essential role in stabilizing chromosomes and therefore protecting them from end-to-end fusion and DNA degradation. Telomere length homeostasis is regulated by several key players including shelterin complex genes, telomerase, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Research and Treatments
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33553693
DOI: 10.1016/j.bbrep.2021.100937

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shelterin complex gene: Prognosis and therapeutic vulnerability in cancerPMID 33553693Read ↗

Pan-cancer analyses reveal regulation and clinical outcome association of the shelterin complex in cancerSemantic proximity Read ↗

TRF1 and TRF2: pioneering targets in telomere-based cancer therapySemantic proximity Read ↗

Telomere-regulating genes and the telomere interactome in familial cancers.Semantic proximity Read ↗

miR-155 Drives Telomere Fragility in Human Breast Cancer by Targeting TRF1Semantic proximity Read ↗

Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectivesSemantic proximity Read ↗

TERT—Regulation and Roles in Cancer FormationSemantic proximity Read ↗

Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest PointSemantic proximity Read ↗

TERT promoter mutations in telomere biology.Semantic proximity Read ↗

Shelterin complex and associated factors at human telomeresSemantic proximity Read ↗

The potential utility of telomere‐related markers for cancer diagnosisSemantic proximity Read ↗

TERT promoter status and gene copy number gains: effect on TERT expression and association with prognosis in breast cancerSemantic proximity Read ↗

Regulation and clinical potential of telomerase reverse transcriptase (TERT/hTERT) in breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.