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G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin

9 Aug 2017

Abstract excerpt

G9a, a H3K9 methyltransferase, shows elevated expression in many types of human cancers, particularly breast cancer. However, the tumorigenic mechanism of G9a is still far from clear. Here we report that G9a exerts its oncogenic function in breast cancer by repressing hephaestin and destruction cellular iron homeostasis. In the case of pharmacological inhibition or short hairpin RNA interference-mediated...

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PMID: 28819251
DOI: 10.1038/s41467-017-00350-9

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