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Article

Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy

6 Feb 2021

Abstract excerpt

The propagation of conformational strains by templated seeding is central to the prion concept. Seeded assembly of α-synuclein into filaments is believed to underlie the prion-like spreading of protein inclusions in a number of human neurodegenerative diseases, including Parkinson's disease, dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). We previously determined the atomic structures of...

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PMID: 33548114
DOI: 10.1002/2211-5463.13110

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