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Article

Biological subphenotypes of acute respiratory distress syndrome may not reflect differences in alveolar inflammation.

Physiological reports - 1 Feb 2021

Heijnen Nanon F L, Hagens Laura A, Smit Marry R, Schultz Marcus J, van der Poll Tom, Schnabel Ronny M, van der Horst Iwan C C, Dickson Robert P, Bergmans Dennis C J J, Bos Lieuwe D J

Abstract excerpt

Biological subphenotypes have been identified in acute respiratory distress syndrome (ARDS) based on two parsimonious models: the "uninflamed" and "reactive" subphenotype (cluster-model) and "hypo-inflammatory" and "hyper-inflammatory" (latent class analysis (LCA) model). The distinction between the subphenotypes is mainly driven by inflammatory and coagulation markers in plasma. However, systemic inflammation is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33547768
DOI: 10.14814/phy2.14693
PMCID: PMC7865405

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MPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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