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Article

ACTG1 regulates intervertebral disc degeneration via the NF-κB-p65 and Akt pathways

2 Feb 2021

Abstract excerpt

ACTG1 is a member of the actin family but is not a muscle actin gene. The ACTG1 mutation leads to hearing loss in humans, and the knockdown of ACTG1 suppresses the proliferation and migration of tumor cells; however, its role in intervertebral disc degeneration (IDD) is yet unclear. Bioinformatics methods revealed that ACTG1 might be a hub gene in IDD. Furthermore, the expression ACTG1 in severely degenerated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33545632
DOI: 10.1016/j.bbrc.2021.01.057

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