Article
Missense, silent, non-sense and frame-shift mutations in exon 3 of the filaggrin gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2021
Salama Ragaa H, Rasheed Zafar, Ahmed Ahmed A, Bin Saif Ghada A, Elkholy Maha M, Abd El-Moniem Alaa E, Salem Tarek, Zedan Khaled, Al Robaee Ahmad A, Alzolibani Abdullateef A
Abstract excerpt
This study investigated the atopic march on the basis of genetics. This research detected 227 variants in the filaggrin gene (FLG gene). Missense, silent, non-sense, frame-shift and non-coding mutations were detected in exon 3 of the FLG gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy. Missense mutation was detected at c.8343 G > C (p. Asp2781Glu) in all adult...
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