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Article

The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs.

Scientific reports - 3 Feb 2021

Ipsen D H, Agerskov R H, Klaebel J H, Lykkesfeldt J, Tveden-Nyborg Pernille

Abstract excerpt

Variability in disease development due to differences in strains and breeders constitutes a substantial challenge in preclinical research. However, the impact of the breeder on non-alcoholic steatohepatitis (NASH) is not yet fully elucidated. This retrospective study investigates NASH development in guinea pigs from Charles River or Envigo fed a high fat diet (20% fat, 15% sucrose, 0.35% cholesterol) for 16 or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33536590
DOI: 10.1038/s41598-021-82643-0
PMCID: PMC7859397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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