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Article

A short deletion in the DNA-binding domain of STAT3 suppresses growth and progression of colon cancer cells.

Aging - 1 Feb 2021

Xiong Yi-Jia, Liu Dong-Yang, Shen Rong-Rong, Xiong Yong

Abstract excerpt

In this study, we investigated the effect of a short deletion in the DNA-binding domain of STAT3 (STAT3del) on the transcriptional activation of STAT3 target genes and its relationship with colon carcinogenesis. We used the CRISPR-CAS9 gene editing system to delete a short sequence encoding amino acids 400-411 in the DNA-binding domain (amino acid sequence: 317-567) from STAT3 gene in SW480, SW620 and HCT116...

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Share to Cell Line, Tumor
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Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 33535185
DOI: 10.18632/aging.202439
PMCID: PMC7950243

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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