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Article

DNA methylation regulates constitutive expression of Stat6 regulatory genes SOCS-1 and SHP-1 in colon cancer cells.

Journal of cancer research and clinical oncology - 1 Dec 2009

Xu Shuang Bing, Liu Xiao Hong, Li Ben Hui, Zhang Yan, Yuan Jia, Yuan Qin, Li Pin Dong, Yang Xian Zi, Li Feng, Zhang Wen Jie

Abstract excerpt

PURPOSE: Stat6 signaling is active in cancer cells and IL-4-induced Stat6 activities or Stat6 activational phenotypes vary among cancer cells. This study aimed at investigating possible mechanism(s) involved in the formation of varying Stat6 activities/phenotypes. METHODS: Stat6 regulatory genes, SOCS-1 and SHP-1, were examined for mRNA expression using RT-PCR, and their promoter DNA methylation was assayed by...

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Identifiers

PMID: 19551406
DOI: 10.1007/s00432-009-0627-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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