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Article

STAT3 Is Necessary for Proliferation and Survival in Colon Cancer–Initiating Cells

7 Sept 2011

Abstract excerpt

STAT3 is constitutively activated in colon cancer but its contributions in cancer-initiating cells have not been explored. In this study, we characterized STAT3 in aldehyde dehydrogenase (ALDH)-positive (ALDH(+)) and CD133-positive (CD133(+)) subpopulations of human colon tumor cells that exhibited more potent tumor-initiating ability than ALDH(-)/CD133(-) cells in tumor xenograft assays in mice. We found that...

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PMID: 21900397
DOI: 10.1158/0008-5472.can-10-4660

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