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Mutations in the coordination spheres of T1 Cu affect Cu2+-activation of the laccase from Thermus thermophilus.

Biochimie - 1 Mar 2021

Clément Romain, Wang Xie, Biaso Frédéric, Ilbert Marianne, Mazurenko Ievgen, Lojou Elisabeth

Abstract excerpt

Thermus thermophilus laccase belongs to the sub-class of multicopper oxidases that is activated by the extra binding of copper to a methionine-rich domain allowing an electron pathway from the substrate to the conventional first electron acceptor, the T1 Cu. In this work, two key amino acid residues in the 1st and 2nd coordination spheres of T1 Cu are mutated in view of tuning their redox potential and...

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PMID: 33535124
DOI: 10.1016/j.biochi.2021.01.006

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