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A toehold-mediated strand displacement cascade-based DNA assay method via flow cytometry and magnetic separation.

Analytical methods : advancing methods and applications - 4 Mar 2021

Ju Ting, Zhai Xingwei, Liu Xinfeng, Han Kun

Abstract excerpt

Sensitive assay of EGFR T790M, a circulating tumor DNA marker in non-small-cell carcinoma, provides critical information for the decision of clinical treatments, evaluation of radiotherapy effect, and monitoring the progress of recurrence and metastasis. In this report, a novel flow cytometry-based sensing method is proposed for detecting T790M. The toehold-sequence hybridizes with the biotin-labeled initiator...

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PMID: 33534873
DOI: 10.1039/d0ay02102d

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