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Association of TLR4 gene polymorphisms with sepsis after a burn injury: findings of the functional role of rs2737190 SNP.

Genes and immunity - 1 May 2021

Colín-Castro Claudia A, Franco-Cendejas Rafael, Rocha-González Hector I, Cruz-Arenas Esteban, Leyva-García Norberto, Sánchez-Sánchez Roberto, Leyva-Gomez Gerardo, Gómez Rocío, Muñoz Balam, Cortés Hernán, Magaña Jonathan J

Abstract excerpt

Sepsis is a life-threatening organ dysfunction condition caused by a dysregulated response to an infection that is common among patients with moderate to severe burn injury. Previously, genomic variants in Toll-like receptor 4 (TLR4), a key innate immunity receptor, have been associated with sepsis and infection susceptibility. In this study, the association of six TLR4 SNPs with sepsis after burn injury was...

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PMID: 33531683
DOI: 10.1038/s41435-021-00121-z

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