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Article

Effect of TLR-4 gene polymorphisms on sepsis susceptibility in neonates: a systematic review and meta-analysis.

Biomarkers in medicine - 1 Sept 2022

Li Ming, Pan Shiguang, Chen Huilin, Yan Shuying, Liu Yuxin

Abstract excerpt

Aim: To clarify the role of polymorphisms rs4986790 and rs4986791 in TLR-4 with susceptibility to neonatal sepsis. Methods: To evaluate the possible correlation of polymorphisms rs4986790 and rs4986791 with sepsis risk, odds ratios (ORs) were calculated. The heterogeneity was evaluated by χ2-based Q-test. Results: For rs4986790, ORs were 1.36 (95% CI: 1.05-1.79, p = 0.017) and 1.84 (95% CI: 0.04-7.9, p = 0.410)...

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Share to Genetic Predisposition to Disease
Share to Infant, Newborn
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Share to Polymorphism, Single Nucleotide
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Share to Toll-Like Receptor 4

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Identifiers

PMID: 36052709
DOI: 10.2217/bmm-2022-0390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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