Article
Discovery of a novel unfolded protein response phenotype of cancer stem/progenitor cells from the bone marrow of breast cancer patients.
Journal of proteome research - 4 Jun 2010
Bartkowiak Kai, Effenberger Katharina E, Harder Sönke, Andreas Antje, Buck Friedrich, Peter-Katalinic Jasna, Pantel Klaus, Brandt Burkhard H
Abstract excerpt
Metastases arise from disseminated tumor cells (DTC) that colonize secondary organs. However, DTC survival strategies to start metastatic outgrowth are unclear. The hostile (hypoxic, hypoglycemic) microenvironmental conditions of the bone marrow serve as an ideal model environment for investigation of DTC survival strategies under environmental stress. We investigated the breast cancer DTC cell line BC-M1...
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