Article

Immune profiling in M. tuberculosis infection enables stratification of patients with active disease

2019-03-18

Abstract excerpt

Tuberculosis (TB) is caused by Mycobacterium tuberculosis ( Mtb ) infection and is a major public health problem with an estimated 1.7 billion persons infected worldwide. Clinical challenges in TB include the lack of a blood-based test for active disease, and the absence of prognostic biomarkers for early treatment response. Current blood based tests, such as QuantiFERON-TB Gold (QFT), are based on an IFNγ reado...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6481d980-e80e-5d03-a0e0-e2d2d2d19f16
DOI: 10.1101/581298

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immune profiling in M. tuberculosis infection enables stratification of patients with active diseaseDOI 10.1101/581298Read

Beyond the Clinic: The Activation of Diverse Cellular and Humoral Factors Shapes the Immunological Status of Patients with Active TuberculosisSemantic proximity Read

Microarray-based selection of a serum biomarker panel that can discriminate between latent and active pulmonary TBSemantic proximity Read

CD38<sup>+</sup>CD27<sup>−</sup> on <i>Mtb</i>-specific CD4<sup>+</sup> T cells distinguishes latent from active tuberculosisSemantic proximity Read

Transcriptional Profiling of Human Peripheral Blood Mononuclear Cells Identifies Diagnostic Biomarkers That Distinguish Active and Latent TuberculosisSemantic proximity Read

Immune endotypes in tuberculosis: Keys to decoding disease complexity.Semantic proximity Read

T-cell immunophenotyping distinguishes active from latent tuberculosis.Semantic proximity Read

Real-time PCR for the rapid identification of latent tuberculosis infection using host-serum biomarkersSemantic proximity Read

Host transcriptional response to TB preventive therapy differentiates two sub-groups of IGRA-positive individualsSemantic proximity Read

Immune profiling of <i>Mycobacterium tuberculosis</i>-specific T cells in recent and remote infectionSemantic proximity Read

Activation Phenotype of Mycobacterium tuberculosis-Specific CD4+ T Cells Promoting the Discrimination Between Active Tuberculosis and Latent Tuberculosis InfectionSemantic proximity Read

Advances in understanding immune homeostasis in latent tuberculosis infectionSemantic proximity Read

Single-cell immune profiling at time of <i>M. tuberculosis</i> exposure reveals antigen-reactive programs that predict progression to active diseaseSemantic proximity Read