Article
Common variant of PDZ domain containing 1 (PDZK1) gene is associated with gout susceptibility: A replication study and meta-analysis in Japanese population.
Drug metabolism and pharmacokinetics - 1 Dec 2016
Higashino Toshihide, Matsuo Hirotaka, Sakiyama Masayuki, Nakayama Akiyoshi, Nakamura Takahiro, Takada Tappei, Ogata Hiraku, Kawamura Yusuke, Kawaguchi Makoto, Naito Mariko, Kawai Sayo, Takada Yuzo, Ooyama Hiroshi, Suzuki Hiroshi, Shinomiya Nariyoshi
Abstract excerpt
PDZ domain containing 1 (PDZK1) is a scaffold protein that organizes a transportsome and regulates several transporters' functions including urate and drug transporters. Therefore, PDZK1 in renal proximal tubules may affect serum uric acid levels through PDZK1-binding renal urate transporters. Two previous studies in Japanese male population reported that a PDZK1 single nucleotide polymorphism (SNP), rs12129861,...
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