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Article

Spatial N-glycomics of the human aortic valve in development and pediatric endstage congenital aortic valve stenosis.

Journal of molecular and cellular cardiology - 1 May 2021

Angel Peggi M, Drake Richard R, Park Yeonhee, Clift Cassandra L, West Connor, Berkhiser Savanna, Hardiman Gary, Mehta Anand S, Bichell David P, Su Yan Ru

Abstract excerpt

Congenital aortic valve stenosis (AS) progresses as an obstructive narrowing of the aortic orifice due to deregulated extracellular matrix (ECM) production by aortic valve (AV) leaflets and leads to heart failure with no effective therapies. Changes in glycoprotein and proteoglycan distribution are a hallmark of AS, yet valvular carbohydrate content remains virtually uncharacterized at the molecular level. While...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

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Identifiers

PMID: 33516683
DOI: 10.1016/j.yjmcc.2021.01.001
PMCID: PMC8722354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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