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Effect of CYP2C9 genetic polymorphism and breviscapine on losartan pharmacokinetics in healthy subjects.

Xenobiotica; the fate of foreign compounds in biological systems - 1 May 2021

Huang Hang-Xing, Wu He, Zhao Yingying, Zhou Tao, Ai Xin, Dong Yu, Zhang Yan, Lai Yong

Abstract excerpt

1. Breviscapine was an active ingredient of flavonoid glycosides. Our present study was conducted to evaluate the impact of breviscapine on the pharmacokinetics of losartan and its active metabolite E-3174, and that relationship with the gene polymorphism of CYP2C9 in healthy Chinese volunteers, to provide a basis for clinical rational drug use.2. The genotypes of 217 healthy Chinese subjects were determined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33509019
DOI: 10.1080/00498254.2021.1880670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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