Article
Next-generation sequencing identifies high frequency of mutations in potentially clinically actionable genes in sebaceous carcinoma.
The Journal of pathology - 1 Sept 2016
Tetzlaff Michael T, Singh Rajesh R, Seviour Elena G, Curry Jonathan L, Hudgens Courtney W, Bell Diana, Wimmer Daniel A, Ning Jing, Czerniak Bogdan A, Zhang Li, Davies Michael A, Prieto Victor G, Broaddus Russell R, Ram Prahlad, Luthra Rajyalakshmi, Esmaeli Bita
Abstract excerpt
Sebaceous carcinoma (SC) is a rare but aggressive malignancy with frequent recurrence and metastases. Surgery is the mainstay of therapy, but effective systemic therapies are lacking because the molecular alterations driving SC remain poorly understood. To identify these, we performed whole-exome next-generation sequencing of 409 cancer-associated genes on 27 SCs (18 primary/locally recurrent ocular, 5 paired...
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