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Profile of copper-associated DNA methylation and its association with incident acute coronary syndrome

27 Jan 2021

Abstract excerpt

BACKGROUND: Acute coronary syndrome (ACS) is a cardiac emergency with high mortality. Exposure to high copper (Cu) concentration has been linked to ACS. However, whether DNA methylation contributes to the association between Cu and ACS is unclear. METHODS: We measured methylation level at > 485,000 cytosine-phosphoguanine sites (CpGs) of blood leukocytes using Human Methylation 450 Bead Chip and conducted a...

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PMID: 33499918
DOI: 10.1186/s13148-021-01004-w

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