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Agricultural copper pesticide exposure and DNA methylation in Central Valley of California residents with and without Parkinson's disease

15 Jul 2025

Abstract excerpt

BACKGROUND: Copper-induced oxidative damage and mitochondrial dysfunction may exacerbate Parkinson's disease (PD) pathology. DNA methylation (DNAm) can serve as a biological mediator of environmental exposures. OBJECTIVE: To investigate the impact of chronic, long-term copper exposure on genome-wide DNA methylation patterns in the blood of PD cases and community controls. METHODS: We analyzed 806 blood samples...

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PMID: 40653069
DOI: 10.1016/j.envres.2025.122335

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