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Genome-wide DNA methylation profiling in blood reveals epigenetic signature of incident acute coronary syndrome

28 Aug 2024

Abstract excerpt

DNA methylation (DNAm) has been implicated in acute coronary syndrome (ACS), but the causality remains unclear in cross-sectional studies. Here, we conduct a prospective epigenome-wide association study of incident ACS in two Chinese cohorts (discovery: 751 nested case-control pairs; replication: 476 nested case-control pairs). We identified and validated 26 differentially methylated positions (DMPs, false...

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PMID: 39198424
DOI: 10.1038/s41467-024-51751-6

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