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Article

DNA methylation biomarkers of myocardial infarction and cardiovascular disease.

Clinical epigenetics - 21 Apr 2021

Fernández-Sanlés Alba, Sayols-Baixeras Sergi, Subirana Isaac, Sentí Mariano, Pérez-Fernández S, de Castro Moura Manuel, Esteller Manel, Marrugat Jaume, Elosua Roberto

Abstract excerpt

BACKGROUND: The epigenetic landscape underlying cardiovascular disease (CVD) is not completely understood and the clinical value of the identified biomarkers is still limited. We aimed to identify differentially methylated loci associated with acute myocardial infarction (AMI) and assess their validity as predictive and causal biomarkers. RESULTS: We designed a case-control, two-stage, epigenome-wide association...

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Cardiovascular Diseases
Cohort Studies
DNA Methylation
Epigenesis, Genetic
Epigenomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myocardial Infarction

Reproducibility of Results

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Identifiers

PMID: 33883000
DOI: 10.1186/s13148-021-01078-6
PMCID: PMC8061080

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