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Article

Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells

25 Jun 2012

Abstract excerpt

Malignant breast tissue contains a rare population of multi-potent cells with the capacity to self-renew; these cells are known as cancer stem-like cells (CSCs) or tumor-initiating cells. Primitive mammary CSCs/progenitor cells can be propagated in culture as floating spherical colonies termed 'mammospheres'. We show here that the expression of the autophagy protein Beclin 1 is higher in mammospheres established...

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PMID: 22733132
DOI: 10.1038/onc.2012.252

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