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Article

Glucocorticoid Receptor Regulates TNFSF11 Transcription by Binding to Glucocorticoid Responsive Element in TNFSF11 Proximal Promoter Region.

International journal of molecular sciences - 21 Jan 2021

Lovšin Nika, Marc Janja

Abstract excerpt

Glucocorticoid osteoporosis is a serious side effect of long term glucocorticoid uptake and it is caused by osteoblast apoptosis and imbalance in the major bone remodeling pathway RANK/RANKL/OPG. The impact of glucocorticoid on the maintenance of RANK/RANKL/OPG is well explored; dexamethasone was shown to disturb the ratio between OPG and RANKL level by decreasing the expression level of OPG and increasing level...

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Share to Cell Line, Tumor
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

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Share to Receptors, Glucocorticoid

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Source

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Identifiers

PMID: 33494362
DOI: 10.3390/ijms22031054
PMCID: PMC7865994

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