Article
Inherited cardiomyopathies as a troponin disease.
The Japanese journal of physiology - 1 Aug 2004
Harada K, Morimoto S
Abstract excerpt
Troponin, one of the sarcomeric proteins, plays a central role in the Ca(2+) regulation of contraction in vertebrate skeletal and cardiac muscles. It consists of three subunits with distinct structure and function, troponin T, troponin I, and troponin C, and their accurate and complex intermolecular interaction in response to the rapid rise and fall of Ca(2+) in cardiomyocytes plays a key role in maintaining the...
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