Article
Crystal digital droplet PCR for detection and quantification of circulating EGFR sensitizing and resistance mutations in advanced non-small cell lung cancer.
PloS one - 1 Jan 2017
Jovelet Cécile, Madic Jordan, Remon Jordi, Honoré Aurélie, Girard Romain, Rouleau Etienne, André Barbara, Besse Benjamin, Droniou Magali, Lacroix Ludovic
Abstract excerpt
Over the past years, targeted therapies using tyrosine kinase inhibitors (TKI) have led to an increase in progression-free survival and response rate for a subgroup of non-small cell lung cancer (NSCLC) patients harbouring specific gene abnormalities compared with chemotherapy. However long-lasting tumor regression is rarely achieved, due to the development of resistant tumoral subclones, which requires...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.