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Article

Single nucleotide polymorphisms in interleukin-6 attenuates hepatocytes injury in hypoxia/re-oxygenation via STAT3 signal pathway mediated autophagy.

Molecular biology reports - 1 Feb 2021

Tang Hongwei, Fang Hongbo, Guo Wenzhi, Cao Shengli, Guo Danfeng, Zhang Huapeng, Gao Jie, Zhang Shuijun

Abstract excerpt

Ischemia-reperfusion injury (IRI) is inevitable during liver surgery, and it is an important factor affecting the prognosis of patients. IL-6 rs1800796 single nucleotide polymorphisms (SNPs) can promote synthesis and secretion of IL-6 and protect hepatocytes from IRI. In this study, we investigated the mechanisms by which IL-6 alleviates hepatic IRI. We transfected lentivirus which carries IL-6 rs1800796 to L02...

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Identifiers

PMID: 33484391
DOI: 10.1007/s11033-020-06090-2
PMCID: PMC7925450

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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