Article
Associations between polymorphisms of interleukin-6 and related cytokine genes and serum liver damage markers: a cross-sectional study in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.
Gene - 25 Feb 2015
Sugimoto Yuka, Wakai Kenji, Nakagawa Hiroko, Suma Shino, Sasakabe Tae, Sakamoto Tatsuhiko, Takashima Naoyuki, Suzuki Sadao, Ogawa Shin, Ohnaka Keizo, Kuriyama Nagato, Arisawa Kokichi, Mikami Haruo, Kubo Michiaki, Hosono Satoyo, Hamajima Nobuyuki, Tanaka Hideo
Abstract excerpt
Cytokines, including interleukin-6 (IL-6), play an important role in the liver. The aim of this study was to investigate associations between common polymorphisms in potential functional promoters of cytokine genes and liver damage markers among enrollees of a large Japanese cohort study. Subjects included 3257 Japanese individuals (1608 men and 1649 women, aged 35-69 years). Six single nucleotide polymorphisms...
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