Article
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.
Nature communications - 10 Sept 2018
Inman Gareth J, Wang Jun, Nagano Ai, Alexandrov Ludmil B, Purdie Karin J, Taylor Richard G, Sherwood Victoria, Thomson Jason, Hogan Sarah, Spender Lindsay C, South Andrew P, Stratton Michael, Chelala Claude, Harwood Catherine A, Proby Charlotte M, Leigh Irene M
Abstract excerpt
Cutaneous squamous cell carcinoma (cSCC) has a high tumour mutational burden (50 mutations per megabase DNA pair). Here, we combine whole-exome analyses from 40 primary cSCC tumours, comprising 20 well-differentiated and 20 moderately/poorly differentiated tumours, with accompanying clinical data from a longitudinal study of immunosuppressed and immunocompetent patients and integrate this analysis with...
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