Article
Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients.
BMC cancer - 5 Feb 2013
Hameetman Liesbeth, Commandeur Suzan, Bavinck Jan Nico Bouwes, Wisgerhof Hermina C, de Gruijl Frank R, Willemze Rein, Mullenders Leon, Tensen Cornelis P, Vrieling Harry
Abstract excerpt
BACKGROUND: The risk of developing cutaneous squamous cell carcinoma (SCC) is markedly increased in organ transplant recipients (OTRs) compared to the normal population. Next to sun exposure, the immunosuppressive regimen is an important risk factor for the development of SCC in OTRs. Various gene mutations (e.g. TP53) and genetic alterations (e.g. loss of CDKN2A, amplification of RAS) have been found in SCCs....
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