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Article

Nonviral gene delivery to T cells with Lipofectamine LTX

22 Jan 2021

Abstract excerpt

Abstract Retroviral gene delivery is widely used in T cell therapies for hematological cancers. However, viral vectors are expensive to manufacture, integrate genes in semirandom patterns, and their transduction efficiency varies between patients. In this study, several nonviral gene delivery vehicles, promoters, and additional variables were compared to optimize nonviral transgene delivery and expression in both...

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PMID: 33480049
DOI: 10.1002/bit.27686

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