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Article

Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24.

Nature communications - 21 Jan 2021

Cao Xiongwen, Khitun Alexandra, Luo Yang, Na Zhenkun, Phoodokmai Thitima, Sappakhaw Khomkrit, Olatunji Elizabeth, Uttamapinant Chayasith, Slavoff Sarah A

Abstract excerpt

Thousands of human small and alternative open reading frames (smORFs and alt-ORFs, respectively) have recently been annotated. Many alt-ORFs are co-encoded with canonical proteins in multicistronic configurations, but few of their functions are known. Here, we report the detection of alt-RPL36, a protein co-encoded with human RPL36. Alt-RPL36 partially localizes to the endoplasmic reticulum, where it interacts...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33479206
DOI: 10.1038/s41467-020-20841-6
PMCID: PMC7820019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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