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Article

Sugar and chromosome stability: clastogenic effects of sugars in vitamin B6-deficient cells.

PLoS genetics - 1 Mar 2014

Marzio Antonio, Merigliano Chiara, Gatti Maurizio, Vernì Fiammetta

Abstract excerpt

Pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, has been implicated in preventing human pathologies, such as diabetes and cancer. However, the mechanisms underlying the beneficial effects of PLP are still unclear. Using Drosophila as a model system, we show that PLP deficiency, caused either by mutations in the pyridoxal kinase-coding gene (dPdxk) or by vitamin B6 antagonists, results in chromosome...

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Identifiers

PMID: 24651653
DOI: 10.1371/journal.pgen.1004199
PMCID: PMC3961173

Genes

PDXK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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