Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy.

mSphere - 20 Jan 2021

Oakley Juliette L, Weiser Rebecca, Powell Lydia C, Forton Julian, Mahenthiralingam Eshwar, Rye Philip D, Hill Katja E, Thomas David W, Pritchard Manon F

Abstract excerpt

Chronic Pseudomonas aeruginosa lung infections in cystic fibrosis (CF) evolve to generate environmentally adapted biofilm communities, leading to increased patient morbidity and mortality. OligoG CF-5/20, a low-molecular-weight inhaled alginate oligomer therapy, is currently in phase IIb/III clinical trials in CF patients. Experimental evolution of P. aeruginosa in response to OligoG CF-5/20 was assessed using a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Alginates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biofilms

Share to Drug Resistance, Multiple, Bacterial

Share to Microbial Sensitivity Tests

Share to Pseudomonas aeruginosa

Share to Pseudomonas Infections

Share to Sputum

Source

Open in PubMed Open full text

Identifiers

PMID: 33472983
DOI: 10.1128/mSphere.01216-20
PMCID: PMC7845618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy.PMID 33472983Read ↗

Pseudomonas aeruginosa Enhances Production of a Non-Alginate Exopolysaccharide during Long-Term Colonization of the Cystic Fibrosis LungSemantic proximity Read ↗

Understanding the control of <i>Pseudomonas aeruginosa</i> alginate synthesis and the prospects for management of chronic infections in cystic fibrosisSemantic proximity Read ↗

Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory InfectionSemantic proximity Read ↗

Transcriptional Response of Mucoid Pseudomonas aeruginosa to Human Respiratory MucusSemantic proximity Read ↗

Evolving stealth: genetic adaptation of Pseudomonas aeruginosa during cystic fibrosis infections.Semantic proximity Read ↗

Exogenous Alginate Protects Staphylococcus aureus from Killing by Pseudomonas aeruginosaSemantic proximity Read ↗

Overcoming drug resistance with alginate oligosaccharides able to potentiate the action of selected antibiotics.Semantic proximity Read ↗

Biofilm Formation in Methicillin-Resistant Staphylococcus aureus Isolated in Cystic Fibrosis Patients Is Strain-Dependent and Differentially Influenced by AntibioticsSemantic proximity Read ↗

NonmucoidPseudomonas aeruginosaExpresses Alginate in the Lungs of Patients with Cystic Fibrosis and in a Mouse ModelSemantic proximity Read ↗

EnhancedIn VitroFormation and Antibiotic Resistance of Nonattached Pseudomonas aeruginosa Aggregates through Incorporation of Neutrophil ProductsSemantic proximity Read ↗

Evolutionary diversification of Pseudomonas aeruginosa in an artificial sputum model.Semantic proximity Read ↗

Mucoid Pseudomonas aeruginosa isolates maintain the biofilm formation capacity and the gene expression profiles during the chronic lung infection of CF patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.